Alpha Hydroxy Acids

Alpha Hydroxy Acids in Cosmetic Dermatology

The cosmetic/drug dilemma: FDA regulation of alpha-hydroxy acids.

Alpha Hydroxy Acids in the Cosmetic Treatment of Photo-induced Skin Ageing

---------------Synopsis The continuous adverse effects of light of over the years add to normai ageing processes. This increases the number and severity of wrinkles, reduces the efficiency of celi mechanisms responsible for the reparation of damaged genes due to UV rays in photo-exposed areas, causes actinic keratosis, slows down epidermic celi turnover and reduces surface lipids, the moisture ...

Alpha Hydroxy Acid (AHA) / Beta Hydroxy Acid (BHA)

AHAs act on both the epidermal and the dermal levels. When applied to the skin, AHAs stimulate the exfoliation of epidermal cells in the stratum corneum (s.c.) by interfering with the ionic bonding between these cells. This results in the sloughing off dull, rough skin and promotes cellular renewal. Initially used for treatment of hyperkeratosis and other skin conditions affecting s.c. turnover...

14-Membered cyclodepsipeptides with alternating beta-hydroxy and alpha-amino acids by cyclodimerization

The cyclodimerization (twinning) of beta-hydroxy acid amides of type 1 under ‘direct amide cyclization’ (DAC) conditions is described. Although other coupling methods also gave moderate results, best yields were obtained via DAC, reaching 88% for the cyclodimer 10. In all cases, when starting with racemic material, only the trans-substituted cyclodepsipeptides were isolated. Simple molecular mo...